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SCF (human):Fc (human) (rec.) (non-lytic)

ART NR.: CHI-HF-220SCF-C050 (50 µg)

Hersteller: Chimerigen

Datenblatt

Anwendungen: Bioassays

Exprimiert in: Hamster cells

Ursprungs-Art: human

Reinheit: >98%

Format: lyophilized

Lagerung: -20°C

Versand: +4°C

UniProt ID: P21583
Suche mit UniProt ID

Geninformationen: GeneID 4254

Schlagworte: MGF, SCF, KITLG, sKITLG, Kit ligand, c-Kit ligand, Stem cell factor, Soluble KIT ligand, Mast cell growth factor

CHI-HF-220SCF-C050

50 µg

286 €

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Bemerkungen: The extracellular domain of human SCF (aa 26-187) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the SCF moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Stem cell factor (SCF), also known as cKit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/cKit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.

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