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SCF (human):Fc (human) (rec.) (non-​lytic)

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Hamster cells human
Erklärungen der Abkürzungen ansehen.
lyophilized BioassaysErklärungen der Abkürzungen ansehen. Chimerigen
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CHI-​HF-​220SCF-​C050 50 µg

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286 €In Warenkorb aufnehmen

The extracellular domain of human SCF (aa 26-​187) is fused at the C-​terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-​filtered solution in PBS. Shows the biological function of the SCF moiety and exerts a prolonged circulating half-​life caused by the modified Fc domain. Stem cell factor (SCF), also known as cKit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-​40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/cKit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.
Cat-Nr:
CHI-HF-220SCF-C050
Menge:
50 µg
Preis:
286 €

UniProt ID: P21583 (Protein knowledgebase)

Schlagworte:
MGF, SCF, KITLG, sKITLG, Kit ligand, c-​Kit ligand, Stem cell factor, Soluble KIT ligand, Mast cell growth factor

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