SC-514

SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6, IL-8, and cyclooxygenase-2 (IC50s = 20, 20, and 8 µM, respectively). SC-514 also reduces NF-kappaB-mediated expression of other genes, including iNOS in LPS-stimulated smooth muscle cells and TLR2 in TNF-activated astrocytes.Formal Name: 4-amino-[2,3'-bithiophene]-5-carboxamide. CAS Number: 354812-17-2. Synonyms: GK 01140. Molecular Formula: C9H8N2OS2. Formula Weight: 224.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. SMILES: NC(=O)c1sc(cc1N)c1cscc1. InChi Code: InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12). InChi Key: BMUACLADCKCNKZ-UHFFFAOYSA-N.