- Search results for SYN-1074-M100
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18 products were found matching "SYN-1074-M100"!
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Item number: SYN-1047-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229...
Keywords: | JNJ38877605 |
Application: | c-MET inhibitor |
CAS | 943540-75-8 |
MW: | 377,4 D |
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Item number: SYN-1054-M100
Soluble in DMSO. Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) >100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4...
Keywords: | Pyridone 6 |
Application: | JAK / Tyk2 inhibitor |
CAS | 457081-03-7 |
MW: | 309,3 D |
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Item number: SYN-1077-M100
Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
Keywords: | SB-590885 |
Application: | BRAF inhibitor |
CAS | 405554-55-4 |
MW: | 453,5 D |
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Item number: SYN-1094-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC(50) of 33nM). It disrupts retroviral budding from cells, apparently by interfering with the endosomal sorting complex required for transport (ESCRT) machinery. In adipocytes, YM-201636 also...
Keywords: | YM-201636 |
Application: | PIKfyve inhibitor |
CAS | 371942-69-7 |
MW: | 503,9 D |
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Item number: SYN-1024-M100
Soluble in DMSO. Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has...
Keywords: | BMS5 |
Application: | LIMK1 / LIMK2 inhibitor |
CAS | 1338247-35-0 |
MW: | 431,3 D |
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Item number: SYN-1078-M100
Soluble in DMSO. SD-06 is a p38 MAP kinase inhibitor. It inhibits p38alpha with an IC(50) value of 170nM and inhibits LPS-stimulated TNF-release in rats. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
Keywords: | SD06 |
Application: | p38 inhibitor |
CAS | 271576-80-8 |
MW: | 397,9 D |
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Item number: SYN-1004-M100
Soluble in DMSO. AG13958 is a VEGF inhibitor that was in clinical development for treatment of age-related macular degeneration (AMD). The drug displays low water solubility and so far in trials delivery has been difficult needing direct injection to be truly effective and it varied by the species used because of...
Keywords: | AG-13958 |
Application: | FLT/TYK receptor inhibitor |
CAS | 319460-94-1 |
MW: | 467,5 D |
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Item number: SYN-1064-M100
Soluble in DMSO or ethanol. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was...
Keywords: | PF562271, PF-562,271 |
Application: | FAK / Pyk2 inhibitor |
CAS | 717907-75-0 |
MW: | 507,5 D |
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Item number: SYN-1070-M100
Soluble in DMSO or ethanol. Purvalanol B is a cyclin-dependent kinase inhibitor with IC(50) values of 6, 6, 9, > 10,000, and 6nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35, respectively. Purvalanol B has also been shown to have anti-proliferative properties, mediated by p42/p44...
Keywords: | NG95 |
Application: | Cyclin-dependent kinase inhibitor inhibitor |
CAS | 212844-54-7 |
MW: | 432,9 D |
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Item number: SYN-1072-M100
Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...
Keywords: | RWJ67657 |
Application: | p38 inhibitor |
CAS | 215303-72-3 |
MW: | 425,5 D |
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Item number: SYN-1079-M100
Soluble in DMSO or ethanol. SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM). Target: MAPK - p38 , Kinase Group: CMGC , Substrate:...
Keywords: | SD169 |
Application: | p38 alpha inhibitor |
CAS | 1670-87-7 |
MW: | 160,2 D |
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Item number: SYN-1034-M100
Soluble in DMSO or ethanol. CYC116 is an orally active small molecule multi-kinase inhibitor with anti-neoplastic activity. CYC116 inhibits Aurora kinases A/B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis....
Keywords: | CYC-116 |
Application: | Aurora A / B inhibitor |
CAS | 693228-63-6 |
MW: | 368,5 D |
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