- Search results for SYN-1073-M100
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21 products were found matching "SYN-1073-M100"!
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Item number: SYN-1037-M100
Soluble in DMSO. Dianilinopyrimidine_01 is a pan tyrosine kinase inhibitor Target: Pan-Tyrosine Kinase , Substrate: Tyrosine
Application: | Pan Tyrosine Kinase inhibitor |
CAS | 916603-07-1 |
MW: | 309,3 D |
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Item number: SYN-1173-M001
Soluble in DMSO or ethanol. SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2. Target: Chk1 , Kinase Group: CAMK , Substrate: Serine-Threonine
Keywords: | MK-8776 |
Application: | Chk1 inhibitor |
CAS | 891494-63-6 |
MW: | 376,3 D |
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Item number: SYN-1077-M100
Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
Keywords: | SB-590885 |
Application: | BRAF inhibitor |
CAS | 405554-55-4 |
MW: | 453,5 D |
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Item number: SYN-1093-M100
Soluble in DMSO or ethanol. The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely...
Keywords: | VX702 |
Application: | P38 inhibitor |
CAS | 745833-23-2 |
MW: | 404,3 D |
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Item number: SYN-1078-M100
Soluble in DMSO. SD-06 is a p38 MAP kinase inhibitor. It inhibits p38alpha with an IC(50) value of 170nM and inhibits LPS-stimulated TNF-release in rats. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
Keywords: | SD06 |
Application: | p38 inhibitor |
CAS | 271576-80-8 |
MW: | 397,9 D |
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Item number: SYN-1003-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Quizartinib (AC220) is a second-generation FLT3 inhibitor that has shown promising activity in AML in Phase II clinical trials. It inhibits mutant and wild-type FLT3 in vivo at 0.1 and 0.5µM, respectively, and has shown favorable activity and tolerability in...
Keywords: | AC220 |
Application: | FLT3 inhibitor |
CAS | 950769-58-1 |
MW: | 560,7 D |
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Item number: SYN-1013-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Tivozanib is a potent inhibitor of VEGFR-1, 2 & 3 (IC(50) 0.21, 0.16 and 0.24nM respectively). Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
Keywords: | AV-951 |
Application: | VEGFR inhibitor |
CAS | 475108-18-0 |
MW: | 454,9 D |
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Item number: SYN-1033-M100
Soluble in DMSO or ethanol. CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has >640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met. Target: HER2 , Kinase Group: RTK , Substrate: Tyrosine
Keywords: | CP724714 |
Application: | HER2 inhibitor |
CAS | 383432-38-0 |
MW: | 469,5 D |
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Item number: SYN-1070-M100
Soluble in DMSO or ethanol. Purvalanol B is a cyclin-dependent kinase inhibitor with IC(50) values of 6, 6, 9, > 10,000, and 6nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35, respectively. Purvalanol B has also been shown to have anti-proliferative properties, mediated by p42/p44...
Keywords: | NG95 |
Application: | Cyclin-dependent kinase inhibitor inhibitor |
CAS | 212844-54-7 |
MW: | 432,9 D |
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Item number: SYN-1072-M100
Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...
Keywords: | RWJ67657 |
Application: | p38 inhibitor |
CAS | 215303-72-3 |
MW: | 425,5 D |
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Item number: SYN-1079-M100
Soluble in DMSO or ethanol. SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM). Target: MAPK - p38 , Kinase Group: CMGC , Substrate:...
Keywords: | SD169 |
Application: | p38 alpha inhibitor |
CAS | 1670-87-7 |
MW: | 160,2 D |
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Item number: SYN-1083-M100
Soluble in DMSO. SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow...
Keywords: | SR-3677 |
Application: | ROCK2 inhibitor |
CAS | 1072959-67-1 |
MW: | 408,5 D |
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