21 products were found matching "SYN-1073-M100"!

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Dianilinopyrimidine_01
Dianilinopyrimidine_01

Item number: SYN-1037-M100

Soluble in DMSO. Dianilinopyrimidine_01 is a pan tyrosine kinase inhibitor Target: Pan-Tyrosine Kinase , Substrate: Tyrosine
Application: Pan Tyrosine Kinase inhibitor
CAS 916603-07-1
MW: 309,3 D
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SCH-900776
SCH-900776

Item number: SYN-1173-M001

Soluble in DMSO or ethanol. SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2. Target: Chk1 , Kinase Group: CAMK , Substrate: Serine-Threonine
Keywords: MK-8776
Application: Chk1 inhibitor
CAS 891494-63-6
MW: 376,3 D
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SB-590885
SB-590885

Item number: SYN-1077-M100

Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
Keywords: SB-590885
Application: BRAF inhibitor
CAS 405554-55-4
MW: 453,5 D
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VX-702
VX-702

Item number: SYN-1093-M100

Soluble in DMSO or ethanol. The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely...
Keywords: VX702
Application: P38 inhibitor
CAS 745833-23-2
MW: 404,3 D
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SD-06
SD-06

Item number: SYN-1078-M100

Soluble in DMSO. SD-06 is a p38 MAP kinase inhibitor. It inhibits p38alpha with an IC(50) value of 170nM and inhibits LPS-stimulated TNF-release in rats. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
Keywords: SD06
Application: p38 inhibitor
CAS 271576-80-8
MW: 397,9 D
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Quizartinib
Quizartinib

Item number: SYN-1003-M100

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Quizartinib (AC220) is a second-generation FLT3 inhibitor that has shown promising activity in AML in Phase II clinical trials. It inhibits mutant and wild-type FLT3 in vivo at 0.1 and 0.5µM, respectively, and has shown favorable activity and tolerability in...
Keywords: AC220
Application: FLT3 inhibitor
CAS 950769-58-1
MW: 560,7 D
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Tivozanib
Tivozanib

Item number: SYN-1013-M100

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Tivozanib is a potent inhibitor of VEGFR-1, 2 & 3 (IC(50) 0.21, 0.16 and 0.24nM respectively). Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
Keywords: AV-951
Application: VEGFR inhibitor
CAS 475108-18-0
MW: 454,9 D
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CP-724714
CP-724714

Item number: SYN-1033-M100

Soluble in DMSO or ethanol. CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has >640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met. Target: HER2 , Kinase Group: RTK , Substrate: Tyrosine
Keywords: CP724714
Application: HER2 inhibitor
CAS 383432-38-0
MW: 469,5 D
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Purvalanol B
Purvalanol B

Item number: SYN-1070-M100

Soluble in DMSO or ethanol. Purvalanol B is a cyclin-dependent kinase inhibitor with IC(50) values of 6, 6, 9, > 10,000, and 6nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35, respectively. Purvalanol B has also been shown to have anti-proliferative properties, mediated by p42/p44...
Keywords: NG95
Application: Cyclin-dependent kinase inhibitor inhibitor
CAS 212844-54-7
MW: 432,9 D
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RWJ-67657
RWJ-67657

Item number: SYN-1072-M100

Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...
Keywords: RWJ67657
Application: p38 inhibitor
CAS 215303-72-3
MW: 425,5 D
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SD-169
SD-169

Item number: SYN-1079-M100

Soluble in DMSO or ethanol. SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM). Target: MAPK - p38 , Kinase Group: CMGC , Substrate:...
Keywords: SD169
Application: p38 alpha inhibitor
CAS 1670-87-7
MW: 160,2 D
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SR3677
SR3677

Item number: SYN-1083-M100

Soluble in DMSO. SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow...
Keywords: SR-3677
Application: ROCK2 inhibitor
CAS 1072959-67-1
MW: 408,5 D
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