- Search results for Cay16281
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6 products were found matching "Cay16281"!
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Item number: Cay16281-5
SB-525334 is a potent inhibitor of the TGF-beta receptor 1 (TGF-beta R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-beta1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-beta1-directed gene...
Keywords: | TGF-beta RI Kinase Inhibitor VIII, 6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]-quinoxaline |
Application: | TGFBR1 inhibitor |
CAS | 356559-20-1 |
MW: | 343.4 D |
From 44.00€
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Item number: Cay16228-1
trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as...
Keywords: | 3-(1H-imidazol-5-yl)-2E-propenoic acid |
Application: | Endogenous UV radiation sensor |
CAS | 3465-72-3 |
MW: | 138.1 D |
From 50.00€
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Item number: Cay16288-1
Tenovin-3 is a small molecule activator of p53 transcriptional activity. It increases p53 activity in MCF-7 cells when used at a concentration of 10 µM. It also increases the level of K40-acetylated alpha-tubulin in H1299 cells and inhibits SIRT2 protein deacetylase activity.Formal Name:...
Keywords: | N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide |
Application: | SIRT2 Inhibitor |
CAS | 1011301-27-1 |
MW: | 327.4 D |
From 130.00€
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Item number: Cay16289-1
TG101348 is a JAK2 inhibitor (IC50 = 3 nM for wild-type and JAK2V617F enzymes). It is 35-, 334-, and 135-fold selective for JAK2 over JAK1, JAK3, and tyrosine kinase 2 (TYK2), respectively. It is also selective for JAK2 over a panel of 34 kinases at 500 nM but does inhibit FMS-related tyrosine kinase 3 (FLT3) and...
Keywords: | Fedratinib, SAR302503,... |
Application: | JAK2 inhibitor |
CAS | 936091-26-8 |
MW: | 524.7 D |
From 77.00€
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Item number: Cay16285-1
TAK-632 is a slow off-rate inhibitor of Raf kinases (IC50s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively). It demonstrates 14-1,200-fold selectivity for Raf over a panel of 26 different kinases. TAK-632 shows significant antiproliferative activity against mutated B-Raf or...
Keywords: | N-[5-[[7-cyano-2-[(cyclopropylcarbonyl)amino]-6-benzothiazolyl]oxy]-2-fluorophenyl]-3-(trifluoromethyl)-benzeneacetamide |
Application: | RAF inhibitor |
CAS | 1228591-30-7 |
MW: | 554.5 D |
From 43.00€
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Item number: Cay16284-1
Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 µM). It is about 10-fold less effective against SRPK2 and does not inhibit the...
Keywords: | SRPK Inhibitor, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide |
Application: | SRPK1 inhibitor |
CAS | 218156-96-8 |
MW: | 349.4 D |
From 43.00€
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