SB-366791

SB-366791
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11019-5 5 mg -

6 - 10 business days*

81.00€
Cay11019-10 10 mg -

6 - 10 business days*

147.00€
Cay11019-25 25 mg -

6 - 10 business days*

347.00€
Cay11019-50 50 mg -

6 - 10 business days*

612.00€
 
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation... more
Product information "SB-366791"
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin. TRPV1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals and plays a role in thermal and mechanical hyperalgesia. SB-366791 is a selective TRPV1 antagonist that is widely used in pain research. In cultured trigeminal ganglion neurons, SB-366791 inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 µM. A 1 nmol injection of SB-366791 in mouse paw reduces capsaicin-induced nociceptive responses in a model of pain. Intrathecal pretreatment of 10 µl SB-366791 in rats suppresses tolerance to the analgesic effects of chronic morphine administration. Co-administration of morphine and SB-366791 at 0.1 mg/kg has potent analgesic effects in a mouse model of bone cancer pain.Formal Name: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide. CAS Number: 472981-92-3. Molecular Formula: C16H14ClNO2. Formula Weight: 287.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.15 mg/ml, DMSO: 10 mg/ml. lambdamax: 297 nm. SMILES: ClC1=CC=C(/C=C/C(NC2=CC(OC)=CC=C2)=O)C=C1. InChi Code: InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+. InChi Key: RYAMDQKWNKKFHD-JXMROGBWSA-N.
Keywords: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
Supplier: Cayman Chemical
Supplier-Nr: 11019

Properties

Application: TRPV1 antagonist
MW: 287.7 D
Formula: C16H14ClNO2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 472981-92-3| Matching products
KEGG ID : K05222 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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