SB 203580

SB 203580
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13067-5 5 mg -

6 - 10 business days*

92.00€
Cay13067-10 10 mg -

6 - 10 business days*

163.00€
Cay13067-50 50 mg -

6 - 10 business days*

448.00€
Cay13067-100 100 mg -

6 - 10 business days*

805.00€
 
Mitogen-activated protein kinases (MAPK) mediate signal transduction from cell surface receptors... more
Product information "SB 203580"
Mitogen-activated protein kinases (MAPK) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 is a pyridinyl imidazole inhibitor of p38 MAPK that specifically blocks its kinase activity. SB 203580 does not however, disrupt JNK activity, which is activated by similar stressors to those which activate p38 MAPK. p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells is inhibited by SB 203580 with an IC50 value of 0.6 µM. SB 203580 also prevents the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1) at IC50 values of 3-5 µM.Formal Name: 4-[4-(4-fluorophenyl)-2-[4-methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine. CAS Number: 152121-47-6. Synonyms: PB 203580, RWJ 64809. Molecular Formula: C21H16FN3OS. Formula Weight: 377.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 226, 318 nm. SMILES: O=S(C)C(C=C1)=CC=C1C(N2)=NC(C3=CC=NC=C3)=C2C4=CC=C(F)C=C4. InChi Code: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25). InChi Key: CDMGBJANTYXAIV-UHFFFAOYSA-N.
Keywords: PB 203580, RWJ 64809, 4-[4-(4-fluorophenyl)-2-[4-methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine
Supplier: Cayman Chemical
Supplier-Nr: 13067

Properties

Application: p38 MAPK inhibitor
MW: 377.4 D
Formula: C21H16FN3OS
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 152121-47-6| Matching products
KEGG ID : K04441 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H318
P Phrases: P264, P270, P280, P330, P301+P310, P305+P351+P338, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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