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The SAPK/JNK pathway is homologous to the MAPK pathway in its overall form but is activated by largely distinct stimuli (1). A variety of extracellular stimuli activate the JNK/SAPK pathway including inflammatory cytokines, UV light, inhibitors of protein synthesis and osmotic stress (1-5). Inflammatory cytokines...

The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines and in some instances, by growth factors and GPCR agonists (1-6). As with the other MAPKs, the...

The stress-activated protein kinase/Junterminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. As with the other MAPKs, the core signaling...

The stress-activated protein kinase/Jun terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. As with the other MAPKs, the core...

Stress-activated protein (SAP) kinases are proline-directed, serine/threonine-specific kinases that require phosphorylation on tyrosine for phosphotransferase activity.SAP Kinase was originally shown to phosphorylate microtubule-associated protein-2, but c-Jun appears to be an important physiological target of this...

Stress-activated protein (SAP) kinases are proline-directed, serine/threonine-specific kinases that require phosphorylation on tyrosine for phosphotransferase activity.SAP Kinase was originally shown to phosphorylate microtubule-associated protein-2, but c-Jun appears to be an important physiological target of this...

The stress-activated protein kinase/Jun- amino-terminal kinase SAPK/JNK is potently and prefer- entially activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, inflamma- tory cytokines and in some instances, by growth factors and GPCR agonists (1-6). As with the other MAPKs,...

Sequence (linear): Gly-Phe-Asp-Leu-Asn-Gly-Gly-Gly-Val-Gly, Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product,...

Mitogen-activated protein (MAP) kinases are activated by dual phosphorylation on threonine and tyrosine residues. The activation is carried out by the family of enzymes known as MAP Kinase Kinases (SKKs, MKKs or MEKs). There are at least four distinct SKKs/MKKs/MEKs identified in mammalian cell types: MKK1/MKK2 that...