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LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.Formal Name: 3,7-dihydro-1-[5S-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione. CAS Number: 100324-80-9. Synonyms: (+)-Lisofylline, (S)-LSF. Molecular Formula: C13H20N4O3. Formula Weight: 280.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/ml, DMSO: 3 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 273 nm. SMILES: O=C(N(C)C1=C2N(C)C=N1)N(CCCC[C@@H](O)C)C2=O. InChi Code: InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m0/s1. InChi Key: NSMXQKNUPPXBRG-VIFPVBQESA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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