(S)-Glycyl-H-1152 (hydrochloride)

(S)-Glycyl-H-1152 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13332-500 500 µg -

6 - 10 business days*

125.00€
Cay13332-1 1 mg -

6 - 10 business days*

236.00€
Cay13332-5 5 mg -

6 - 10 business days*

975.00€
Cay13332-10 10 mg -

6 - 10 business days*

1,706.00€
 
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to... more
Product information "(S)-Glycyl-H-1152 (hydrochloride)"
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK2). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca2+/calmodulin-dependent kinase type II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 µM, respectively) as well as PKA or PKC (IC50 >10 µM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).Formal Name: 2-amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]-ethanone, dihydrochloride. CAS Number: 913844-45-8. Synonyms: Rho Kinase Inhibitor IV. Molecular Formula: C18H24N4O3S . 2HCl. Formula Weight: 449.4. Purity: >98%. Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 216, 280, 328 nm. SMILES: O=S(C1=CC=CC2=C1C(C)=CN=C2)(N3CCCN(C(CN)=O)C[C@@H]3C)=O. InChi Code: InChI=1S/C18H24N4O3S/c1-13-10-20-11-15-5-3-6-16(18(13)15)26(24,25)22-8-4-7-21(12-14(22)2)17(23)9-19/h3,5-6,10-11,14H,4,7-9,12,19H2,1-2H3/t14-/m0/s1. InChi Key: CMKMGFAUKPAOMG-AWEZNQCLSA-N.
Keywords: Rho Kinase Inhibitor IV, 2-amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]-ethanone, dihydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 13332

Properties

Application: ROCK inhibitor
MW: 449.4 D
Formula: C18H24N4O3S . 2HCl
Purity: >98%
Format: Solution

Database Information

CAS : 913844-45-8| Matching products
KEGG ID : K04514 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H301, H311, H331, H370
P Phrases: P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+310, P302+352, P303+361+353, P304+340, P308+311, P311, P312, P321, P330, P361+364, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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