(S)-Duloxetine (hydrochloride)

(S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes). It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively). It also decreases immobility time and increases latency to first immobility in the forced swim test in mice when administered at doses of 16 and 32 mg/kg. Formulations containing (S)-duloxetine have been used in the treatment of major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia.Formal Name: N-methyl-gammaS-(1-naphthalenyloxy)-2-thiophenepropanamine, monohydrochloride. CAS Number: 136434-34-9. Synonyms: LY248686. Molecular Formula: C18H19NOS . HCl. Formula Weight: 333.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 217, 291 nm. SMILES: CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl. InChi Code: InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16,/h2-10,13,17,19H,11-12H2,1H3,1H/t17-,/m0./s1. InChi Key: BFFSMCNJSOPUAY-LMOVPXPDSA-N.