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Item number: Cay14317-25

(S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes). It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg,...

Keywords:	LY248686, N-methyl-gammaS-(1-naphthalenyloxy)-2-thiophenepropanamine, monohydrochloride
Application:	Serotonin and norepinephrine reuptake inhibitor
CAS	136434-34-9
MW:	333.9 D

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