14 products were found matching "SYN-1172-M100"!

Solid. Soluble in DMSO. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block...

Slightly soluble (<1mg/ml) in DMSO or ethanol. Tamatinib effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals. Target: BCR , Kinase Group: PTK , Substrate: Tyrosine

Soluble in DMSO or ethanol. MK-2206 is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC(50) of 8nM, 12nM and 65nM, respectively. Target: AKT , Kinase Group: AGC , Substrate: Serine-Threonine

Soluble in DMSO or ethanol. SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2. Target: Chk1 , Kinase Group: CAMK , Substrate: Serine-Threonine

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn inhibitor with IC(50) values of 5.8nM and 19nM, respectively.

Soluble in DMSO. CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively. Target: PKC - PKC alpha, , Kinase Group: STE , Substrate: Serine-Threonine

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies. Target: PI3K , Kinase Group: Atypical (PIKK) ,...

Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...

Soluble in DMSO. S6K-18 is a highly selective inhibitor of S6K1, with an IC(50) of 52nM. Target: S6K , Kinase Group: AGC , Substrate: Serine-Threonine

Soluble in DMSO or ethanol. NVP-BGJ398 inhibits FGFR-WT, FGFR2-WT, FGFR3-K650E, FGFR3-S249C and FGFR4-WT with IC(50) values of 4.6, 4.9, 5, 5 and 168nM, respectively. Target: FGFR , Kinase Group: RTK , Substrate: Tyrosine

Soluble in DMSO or ethanol. BMS-599626 is an orally bioavailable, highly selective and potent pan-HER kinase inhibitor. It inhibits HER1 and HER2 with IC(50) values of 20 and 30nM, respectively. Target: EGFR - HER2 , Kinase Group: RTK , Substrate: Tyrosine