- Search results for Cay10010260
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5 products were found matching "Cay10010260"!
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Item number: Cay10010260-50
Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2 over COX-1 with IC50 values of 0.018 and >15 µM, respectively, for production of prostaglandin E2 (PGE2, Cay-14010) in CHO cells expressing the recombinant human enzymes. In vivo, rofecoxib inhibits carrageenan-induced paw...
Keywords: | MK-966, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone |
Application: | COX-2 inhibitor |
CAS | 162011-90-7 |
MW: | 314.4 D |
From 115.00€
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Item number: Cay10010266-10
The transcription factor NF-kappaB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. In the cytoplasm, inactive NF-kappaB complexes are bound to an inhibitor IkappaB. However in response to certain...
Keywords: | 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile |
Application: | NF-kappaB activation inhibitor |
CAS | 19542-67-7 |
MW: | 207.3 D |
From 66.00€
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Item number: Cay10010267-10
SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6,...
Keywords: | 4-amino-[2,3'-bithiophene]-5-carboxamide |
Application: | IKK2 inhibitor |
CAS | 354812-17-2 |
MW: | 224.3 D |
From 60.00€
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Item number: Cay10010265-10
LFM-A13 is an inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 2.5 µM). It is selective for BTK over JAK1, JAK3, IRK, EGFR, and HCK (IC50s = >278 µM for all), as well as a panel of seven serine/threonine and 10 tyrosine kinases as well as one lipid kinase (IC50s = >200-500 µM), but does inhibit polo-like kinase 3...
Keywords: | 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide |
Application: | Tyrosine kinase inhibitor |
CAS | 244240-24-2 |
MW: | 360 D |
From 92.00€
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Item number: Cay10010268-10
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 µM). It has been used to differentiate rat mesenchymal stem...
Keywords: | NSC 678027, RG-14355, 5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid |
Application: | EGFR inhibitor |
CAS | 125697-92-9 |
MW: | 381.4 D |
From 109.00€
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