Human resistin were expressed in E. coli and purified to >98%. Resistance to insulin characterizes type 2 diabetes, the most common form of diabetes. There is a strong link between type 2 diabetes and obesity, as most patients tend to be obese. Thiozolidinediones (TZDs), a new class of anti-diabetic drugs, enhances...

Cell-permeable. A TGF-b type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC??=4nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the direct reprogramming of mouse fibroblasts through induction of Nanog transcription. Solubility: DMSO (>20mg/ml),...

Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue- Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a...

Resistin (resistanceto insulin), also known as adipocytespecific secretory factor (ADSF) and, found in inflammatory zone 3 (FIZZ3), is a 10kD member of a small family of secreted cysteinerich peptide hormones. These molecules purportedly play some role in inflammation, glucose metabolism, and angiogenesis (1, 2, 3,...