RbBP5 (human, recombinant)

Retinoblastoma-binding protein 5 (RbBP5) is a ubiquitously expressed nuclear protein that contains WD40 repeat-like domains. RbBP5 binds directly to tumor suppressor retinoblastoma protein (RB) and regulates cell proliferation. Interaction of RbBP5 occurs preferentially with underphosphorylated RB through the E1A-binding pocket B. RbBP5 is also an important component of the multi-subunit SET1 lysine methyltransferase protein complex, which includes MLL1. RbBP5 interacts directly with WDR5 contributing to the activation of the MLL1 core protein complex. MLL1-4 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation.Synonyms: RBQ3, Retinoblastoma binding Protein 5, SWD1, Set1c WD40 repeat protein, homolog. Purity: >90%. Source: Recombinant protein expressed in E. coli. Amino Acids: 2-538 (full length). MW: 72.9 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol. License: SUMOpro tag was used under non-exclusive license from LifeSensors, Inc.. UniProt Accession #: Q15291.