Rasagiline

Rasagiline is an inhibitor of monoamine oxidase B (MAO-B, IC50 = 4.43 nM for rat brain enzyme). It is selective for MAO-B over MAO-A (IC50 = 412 nM for rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM. Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg). It reduces cerebral edema in a mouse model of traumatic brain injury. Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces alpha-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease. Formulations containing rasagiline have been used in the treatment of Parkinson's disease.Formal Name: (1R)-2,3-dihydro-N-2-propyn-1-yl-1H-inden-1-amine. CAS Number: 136236-51-6. Synonyms: (R)-(+)-Rasagiline. Molecular Formula: C12H13N. Formula Weight: 171.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:9): 0.10 mg/ml. lambdamax: 265, 272 nm. SMILES: C#CCN[C@H]1C2=CC=CC=C2CC1. InChi Code: InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1. InChi Key: RUOKEQAAGRXIBM-GFCCVEGCSA-N.