18 products were found matching "SYN-1185-M100"!

Soluble in DMSO. GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2µM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in...

Soluble in DMSO. AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.

Soluble in DMSO. CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively. Target: PKC - PKC alpha, , Kinase Group: STE , Substrate: Serine-Threonine

Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to...

Soluble in DMSO or ethanol. AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with an IC(50) of 7nM. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. TG100115 inhibits PI3K gamma and delta, with IC(50) values of 83 and 235nM, respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45nM, respectively. SAR131675 dose dependently inhibited the proliferation of primary...

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies. Target: PI3K , Kinase Group: Atypical (PIKK) ,...

Soluble in DMSO. XL388 is a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR) with an IC(50) of 9.9nM.

Soluble in DMSO. GNE-493 is a potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor for the treatment of cancer. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

Soluble in DMSO or ethanol. Brivanib inhibitors VEGFR -2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM. Target: FGFR - VEGFR ,...

Soluble in DMSO. NIBR-17 is a pan class I PI3K inhibitor with IC(50) values of 1, 9.2, 9 and 20nM, respectively for PI3Kalpha - delta. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid