- Search results for Cay15745
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7 products were found matching "Cay15745"!
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Item number: Cay11574-5
Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2, IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively). It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM....
Keywords: | (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol |
Application: | SGLT inhibitor |
CAS | 461432-26-8 |
MW: | 408.9 D |
From 44.00€
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Item number: Cay15574-5
(±)-Nutlin-3 (Cay-10004372) blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as...
Keywords: | 4-(4-bromophenyl)-1-[(4-fluorophenyl)methyl]-4,5-dihydro-5-[3-(1H-imidazol-1-yl)propyl]-3-phenyl-pyrrolo[3,4-c]pyrazol-6(1... |
Application: | p53-Mdm2 interaction inhibitor |
CAS | 1542066-74-9 |
MW: | 570.5 D |
From 158.00€
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Item number: Cay15774-5
6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity. Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases,...
Keywords: | 6-TG, NSC 752, NSC 76504, 2-amino-1,9-dihydro-6H-purine-6-thione |
Application: | Double-strand break inducer |
CAS | 154-42-7 |
MW: | 167.2 D |
From 43.00€
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Item number: Cay15784-5
Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT5, which consists of two...
Keywords: | Signal Transducers and Activators of Transcription 5, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide... |
Application: | Cell permeable STAT5 inhibitor |
CAS | 285986-31-4 |
MW: | 293.3 D |
From 92.00€
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Item number: Cay15074-5
JWH 018 (Cay-10900) is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor with Ki values of 9.0 and 2.94 nM for the central cannabinoid (CB1) and CB2 receptors, respectively. JWH 018 benzimidazole analog replaces the indole core of JWH 018 with a benzimidazole core. While the physiological and...
Keywords: | BIM-018, naphthalen-1-yl(1-pentyl-1H-benzo[d]imidazol-2-yl)methanone |
Application: | Analytical reference standard, Synthetic cannabinoid analog |
CAS | 2316839-70-8 |
MW: | 342.4 D |
From 109.00€
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Item number: Cay15174-5
ML-097 is a small molecule pan activator of Ras-related GTPases, activating cell division cycle 42, Ras, and Rac1 with EC50 values of 102, 109, and 151 nM, respectively.Formal Name: 2-[(2-bromophenyl)methoxy]-benzoic acid. CAS Number: 743456-83-9. Synonyms: CID-2160985. Molecular Formula: C14H11BrO3. Formula Weight:...
Keywords: | CID-2160985, 2-[(2-bromophenyl)methoxy]-benzoic acid |
Application: | Ras-related GTPase activator |
CAS | 743456-83-9 |
MW: | 307.1 D |
From 60.00€
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Item number: Cay15374-5
Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity. Taurolidine and its metabolites mimic mannose by binding to the extracellular wall of bacteria, blocking adherence to epithelial and fibroblast cells. In addition to...
Keywords: | 4,4'-methylenebis(tetrahydro-1,2H,4-thiadiazine) 1,1,1',1'-tetraoxide |
Application: | Antimicrobial mannose mimic |
CAS | 19388-87-5 |
MW: | 284.4 D |
From 43.00€
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