3 products were found matching "Cay15744"!
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Dapagliflozin
Item number: Cay11574-10
Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2, IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively). It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM....
| Keywords: | (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol |
| Application: | SGLT inhibitor |
| CAS | 461432-26-8 |
| MW: | 408.9 D |
From 44.00€
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6-Thioguanine
Item number: Cay15774-250
6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity. Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases,...
| Keywords: | 6-TG, NSC 752, NSC 76504, 2-amino-1,9-dihydro-6H-purine-6-thione |
| Application: | Double-strand break inducer |
| CAS | 154-42-7 |
| MW: | 167.2 D |
From 43.00€
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CAY10682
Item number: Cay15574-5
(±)-Nutlin-3 (Cay-10004372) blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as...
| Keywords: | 4-(4-bromophenyl)-1-[(4-fluorophenyl)methyl]-4,5-dihydro-5-[3-(1H-imidazol-1-yl)propyl]-3-phenyl-pyrrolo[3,4-c]pyrazol-6(1... |
| Application: | p53-Mdm2 interaction inhibitor |
| CAS | 1542066-74-9 |
| MW: | 570.5 D |
From 158.00€
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