This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
HDM-2 (human double minute-2, MDM-2 in mouse) is a key negative regulator of p53 that binds to and targets p53 for proteasomal degradation. Overexpression of HDM-2 in some tumors leads to inactivation of p53 thereby allowing tumor cells to escape p53-induced apoptosis. RITA is an inhibitor of the protein-protein interaction between p53 and human double minute-2 (HDM-2). It binds to p53 with an apparent Kd value of 1.5 nM and prevents the interaction between p53 and HDM-2. RITA induces DNA damage and apoptosis in, as well as inhibits the growth of, A498, TK-10, ACHN, and UO-31 renal carcinoma cells (GI50s = 0.017, 0.032, 22.76, and 41.71 µM, respectively). In vivo, RITA (10 mg/kg) reduces tumor volume in an HCT116 mouse xenograft model. It also induces complete tumor regression in an A498 mouse xenograft model when administered at a dose of 45 mg/kg.Formal Name: 5,5'-(2,5-furandiyl)bis-2-thiophenemethanol. CAS Number: 213261-59-7. Synonyms: 2,5-bis(5-hydroxymethyl-2-thienyl) Furan, NSC 652287, Reactivation of p53 and Induction of Tumor Cell Apoptosis. Molecular Formula: C14H12O3S2. Formula Weight: 292.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): .5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 265, 359 nm. SMILES: OCc1ccc(s1)c1ccc(o1)c1ccc(CO)s1. InChi Code: InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2. InChi Key: KZENBFUSKMWCJF-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information