9 products were found matching "Cay15755"!

Zaleplon (Cay-11577) is an analytical reference material that is functionally categorized as a sedative. It is a pyrazolopyrimidine that selectively activates the GABAA alpha1 receptor subunit (EC50 = 1.1 µM), producing a sedative effect. It is characterized as being an ultra-short-acting sedative due to short Tmax...

Ramiprilat is the active metabolite of ramipril (Cay-15558) and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported...

Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2, IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM). Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals. Formulations...

Carmustine is a DNA alkylating agent. It inhibits cell growth and induces cell cycle arrest at the G2/M phase in C6 rat glioma cells when used at a concentration of 10 µM. In vivo, carmustine (0.3 and 6.7 mg/kg per day) reduces tumor growth in a C6 rat glioma model. Carmustine (0.5 mg/kg, i.p.) also reduces the...

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a...

epi-Testosterone (Cay-15875) is an analytical reference material categorized as an anabolic androgenic steroid. epi-Testosterone has been used as a masking agent for testosterone in sports doping. epi-Testosterone is regulated as a Schedule III compound in the United States. This product is intended for research and...

Bufalin is a cardiotonic steroid first isolated from toad venom and used in traditional Asian medicine. It inhibits the Na+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the alpha1, alpha2, and alpha3 subunits, respectively). Intravenously administered bufalin is cleared rapidly, with a plasma half-life of 25...

Signaling through small G proteins of the RhoA subfamily, including RhoC, induces actin-regulated cytosolic-to-nuclear translocation of the oncogene product megakaryoblastic leukemia 1 (MKL1), which binds to serum response factor (SRF). The MKL1/SRF complex, in turn, activates the transcription of serum response...

The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP....