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RANK Receptor human recombinant produced in E. coli is a single, non-glycosylated polypeptide... more
Product information "RANK Receptor, soluble, human recombinant (rHuRANKReceptor)"
RANK Receptor human recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 174 amino acids and having a molecular mass of 19.1 kDa. sRANK Receptor is a part of of the TNF superfamily of ligands and receptors which participates in the regulation of specific immunity and bone turnover. sRANK Receptor was originally acknowledged as a dendritic-cell-membrane protein, which by interacting with RANKL augments the capacity of dendritic cells to stimulate native T cell proliferation and to endorse the survival of RANK and T cells. The full length human RANK cDNA encodes a type I transmembrane protein of 616 amino acids with a predicted 183 amino acid extracellular domain and a 383 amino acid cytoplasmic domain. sRANK Receptor is also expressed in a various tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Keywords: | RANK, ODFR, CD265, TNFRSF11A, Receptor activator of NF-KB, Osteoclast differentiation factor receptor, Tumor necrosis factor receptor superfamily member 11A |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97643 |
Properties
Application: | Cell culture |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 19100 D |
Purity: | >98% |
Format: | Lyophilized |
Database Information
KEGG ID : | K05147 | Matching products |
UniProt ID : | Q9Y6Q6 | Matching products |
Gene ID | GeneID 8792 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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