(R)-MG132

(R)-MG132
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13697-1 1 mg -

6 - 10 business days*

60.00€
Cay13697-5 5 mg -

6 - 10 business days*

271.00€
Cay13697-10 10 mg -

6 - 10 business days*

457.00€
Cay13697-25 25 mg -

6 - 10 business days*

1,066.00€
 
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of... more
Product information "(R)-MG132"
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 µM (ChTL), 34.4 versus 104.43 µM (TL), 2.95 versus 5.70 µM (PGPH), respectively).Formal Name: N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-formyl-3-methylbutyl]-L-leucinamide. CAS Number: 1211877-36-9. Molecular Formula: C26H41N3O5. Formula Weight: 475.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml. SMILES: O=CC[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1. InChi Code: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1. InChi Key: TZYWCYJVHRLUCT-ZRBLBEILSA-N.
Keywords: N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-formyl-3-methylbutyl]-L-leucinamide
Supplier: Cayman Chemical
Supplier-Nr: 13697

Properties

Application: Proteasome inhibitor
MW: 475.6 D
Formula: C26H41N3O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1211877-36-9| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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