(R)-CR8

(R)-CR8
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14006-1 1 mg -

6 - 10 business days*

77.00€
Cay14006-5 5 mg -

6 - 10 business days*

240.00€
Cay14006-10 10 mg -

6 - 10 business days*

369.00€
 
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore... more
Product information "(R)-CR8"
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-CR8 is a second-generation analog of (R)-roscovitine (Cay-10009569) that inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T with IC50 values of 0.09, 0.072, 0.041, 0.11, and 0.18 µM, respectively. (R)-CR8 has 2- to 4-fold improved potency for the inhibition of CDKs over (R)-roscovitine and can inhibit the proliferation of various cancer cell lines with ~40-fold more potency than (R)-roscovitine (IC50s ~ 0.39 versus 27.8 µM, respectively). (R)-CR8 also inhibits casein kinase 1 (CK1delta/epsilon) with an IC50 value of 0.40 µM and inhibits GSK3alpha/beta with an IC50 value of 12 µM.Formal Name: 2R-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol. CAS Number: 294646-77-8. Molecular Formula: C24H29N7O. Formula Weight: 431.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Ethanol: Soluble. lambdamax: 232, 290 nm. SMILES: CC(C)N(C=N1)C2=C1C(NCC3=CC=C(C4=NC=CC=C4)C=C3)=NC(N[C@H](CC)CO)=N2. InChi Code: InChI=1S/C24H29N7O/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12,15-16,19,32H,4,13-14H2,1-3H3,(H2,26,28,29,30)/t19-/m1/s1. InChi Key: HOCBJBNQIQQQGT-LJQANCHMSA-N.
Keywords: 2R-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol
Supplier: Cayman Chemical
Supplier-Nr: 14006

Properties

Application: CDK Inhibitor
MW: 431.5 D
Formula: C24H29N7O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 294646-77-8| Matching products
KEGG ID : K02206 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302
P Phrases: P264, P270, P301+310, P330, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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