(R)-Bromoenol lactone

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase gamma (iPLA2gamma). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2beta except at high doses of 20-30 µM. (R)-BEL inhibits human recombinant iPLA2gamma with an IC50 of approximately 0.6 µM.Formal Name: 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl)-2H-pyran-2-one. CAS Number: 478288-90-3. Synonyms: (R)-BEL. Molecular Formula: C16H13BrO2. Formula Weight: 317.2. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): .05 mg/ml. lambdamax: 222, 280 nm. SMILES: Br/C=C(CC1)/OC([C@@]1([H])C2=CC=CC3=CC=CC=C32)=O. InChi Code: InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+/t15-/m1/s1. InChi Key: BYUCSFWXCMTYOI-HBIYDYFMSA-N.