7 products were found matching "Cay14941"!

Quinolinic acid is an active metabolite of tryptophan (Cay-29600, Cay-31210) and an NMDA receptor agonist. It is formed from tryptophan via the kynurenine pathway. Quinolinic acid (100 µM) induces lipid peroxidation in rat brain synaptosomes, an effect that can be reversed by the NMDA receptor antagonist...

Ponatinib is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor (IC50 = 0.37 nM). It inhibits the tyrosine kinase inhibitor-resistant mutant Bcr-AblT315I (IC50 = 2 nM), as well as Bcr-AblQ252H, Bcr-AblY253F, Bcr-AblM351T, and Bcr-AblH396P mutants (IC50s = 0.44, 0.3, 0.3, and 0.34 nM, respectively). It is...

Metyrapone is an inhibitor of the cytochrome P450 (CYP) enzyme 11beta-hydroxylase (IC50 = 7.83 µM), an enzyme involved in the final step of cortisol biosynthesis. It also induces Cyp1a1 and Cyp3a4 expression in rat hepatic microsomes and inhibits the activity of 11beta-hydroxysteroid dehydrogenase type 1...

Calcein AM is a cell-permeable dye that, upon entering live cells, is cleaved by intracellular esterases, leaving membrane-impermeant calcein (Cay-16221), a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively. It can be used as an indicator of cell viability, cell-cell...

24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro...

Resveratrol-3-O-sulfate is a metabolite of resveratrol (Cay-70675, Cay-10004235). In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 µM) decreases the expression of IL-1alpha, IL-1beta, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-alpha and IL-6 to similar levels as...

20-ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of PGE2 in which the omega-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma...