8 products were found matching "Cay11130"!

The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...

1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28...

Pterostilbene is a polyketide synthase-derived stilbene originally isolated from P. santalinus that has diverse biological activities. It reduces photooxidative leakage induced by the herbicide acifluorfen in C. sativus cotyledon disks when used at a concentration of 30 µg/ml. Pterostilbene (25 and 50 µM) inhibits...

Methylation of lysine residues in core histones plays a critical role in regulating gene expression. Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), leading to transcriptional repression and activation, respectively. Like...

Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM. While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.Formal Name:...

Phencyclidine (PCP), known more commonly as angel dust, is a psychoactive drug that is regulated as a schedule I compound in the United States. 4-methoxy PCP is an analog of PCP which has recently been commercially produced as a designer drug. It preferentially binds the sigma-2 receptor (Ki = 143 nM) and less...

Formation of cis monoenoic acids from unsaturated fatty acids, such as palmitoleic acid (9-cis-hexadecenoic acid) from palmitic acid occurs readily in animal tissues. Delta2-trans-Hexadecenoic acid is an intermediate formed in the beta-oxidation of palmitic acid. In a model meant to simulate gastric ulceration,...

One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems. The cellular membranes of autotrophic bacteria contain mono-unsaturated fatty acids. The specific composition and abundance of...