10 products were found matching "Cay10503-200"!

Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain,...

The Prostaglandin Screening Library III contains more than 70 "A and J-series" of prostaglandins in a 96-well Matrix tube rack format as 2 mM stocks in DMSO. The library may also include thromboxanes, lactones, stable PGH, prostacyclin mimic, metabolites, and potent PGA and PGJ analogs. Stability data is not...

Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid through an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide...

CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 µM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight...

Lauric acid is a common 12-carbon saturated fatty acid plentiful in coconut and other nut oils. Saturated fatty acids induce the expression of cyclooxygenase-2, an effect that is significant at 25 µM in RAW 264.7 cells, with lauric acid being the most potent of the C:8-18 fatty acids. Lauric acid ethyl ester is a...

Abnormal cannabidiol-d3 (Cay-10009523) is intended for use as an internal standard for the quantification of abnormal cannabidiol (Cay-10004259) by GC- or LC-MS. Abnormal cannabidiol is structurally similar to known phytocannabinoids. It is a bioproduct in the synthesis of cannabidiol. Abnormal cannabidiol is not...

Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase. SET7/9 methylates histone H3, tumor suppressor p53, and transcription...

L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.Formal Name:...

CAY10444 is a sphingosine-1-phosphate receptor 3 (S1P3) antagonist. It inhibits S1P-induced calcium mobilization in CHO cells expressing human S1P3 (IC50 = 11.6 µM). CAY10444 (5 µM) inhibits S1P-induced growth and migration of MH7A rheumatoid fibroblast-like synoviocyte cells. It inhibits the localization and...

G-418 is an aminoglycoside antibiotic. It is active against T. thermophila (IC50 = 10 µM). It inhibits the 80S ribosome and protein elongation during translation in a cell-free assay when used at a concentration of 2 nM. G-418 is used in molecular biology as a selective agent in cell lines or plasmids containing the...