Prostaglandin D2 FPIA Kit (green)
ART NR.: Cay500581-384 (384 wells)
Schlagworte: PGD2 Fluorescence Polarization Immunoassay - Green
Prostaglandin D2 (PGD2) is biosynthesized in the brain by a glutathione-independent lipocalin-type PGD2 synthase (L-PGDS). It accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans. PGD2 is also synthesized by mast cells and leukocytes by a cellular, myeloid-type, glutathione-dependent PGD synthase (hematopoietic PGD Synthase, H-PGDS). In this setting, PGD2 and acts as a pro-inflammatory mediator in allergic reactions following release in large amounts from allergen-stimulated mast cells. Caymans PGD2 Fluorescence Polarization Immunoassay (FPIA) is especially designed for High Throughput Screening (HTS) applications for direct, rapid measurement of PGD2. The assay is particularly suited for samples from cell culture and purified enzyme preparations. The PGD2-FPIA is robust (Z = 0.74), exhibits D120 mP over a range of 244 pg/ml to 1,000 ng/ml PGD2, and has a detection limit of 470 pg/ml.
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