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Progranulin (human, rec.)

ART NR.: AG-40A-0068-C010 (10 µg)
AG-40A-0068-C050 (50 µg)

Hersteller: Adipogen

Datenblatt



MSDS

Anwendungen: Bioassays

Exprimiert in: Human cells

Ursprungs-Art: human

MW: 90 kD

Format: liquid

UniProt ID: P28799
Suche mit UniProt ID

Schlagworte: Proepithelin, PEPI, PC Cell-derived Growth Factor

AG-40A-0068-C010

10 µg

187 €

AG-40A-0068-C050

50 µg

385 €

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Bemerkungen: Signal peptide and human progranulin (amino acids 1-593) are fused at the C-terminus to a FLAG(R)-tag. Activates ERK phosphorylation in THP-1 and MCF10A cells and induces cell migration of THP-1 monocytic leukemia cells. Liquid. 0.2µm-filtered solution in PBS. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Image Art AG-40A-0068-C050 Adipogen Progranulin (human, rec.)
Figure legend: Datenblatt ansehen

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