6 products were found matching "Cay14981"!

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Probenecid
Probenecid

Item number: Cay14981-5

Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) and the ATP-binding cassette transporter (ABCC1) multidrug resistance protein 1 (MRP1) and activates the transient receptor potential (TRP) channel TRPV2. It inhibits OAT1, OAT3, and OAT6 (Kis = 6.3, 9.0, and 8.4 µM,...
Keywords: NSC 18786, 4-[(dipropylamino)sulfonyl]-benzoic acid
Application: Uricosuric, organic anion transporter inhibitor
CAS 57-66-9
MW: 285.4 D
From 43.00€ *
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Ac-DEVD-AMC
Ac-DEVD-AMC

Item number: Cay14986-1

Ac-DEVD-AMC is a fluorogenic substrate that can be cleaved specifically by caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.Formal Name:...
Keywords: Caspase-3 Substrate (Fluorogenic), N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin,...
Application: Fluorogenic caspase-3 substrate
CAS 169332-61-0
MW: 675.6 D
From 82.00€ *
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Z-AEVD-FMK
Z-AEVD-FMK

Item number: Cay14987-1

Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases. At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.Formal Name:...
Keywords: Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone,...
Application: Irreversible caspase-10 inhibitor
CAS 1135688-47-9
MW: 610.6 D
From 92.00€ *
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Sp-Cyclic AMPS (sodium salt)
Sp-Cyclic AMPS (sodium salt)

Item number: Cay14983-1

Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases. Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF...
Keywords: Sp-cAMPS, cyclic 3',5'-[hydrogen (S)-phosphorothioate] adenosine, monosodium salt
Application: cAMP derivate, binds to PDE10 GAF domain
CAS 142439-95-0
MW: 367.3 D
From 92.00€ *
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Ac-VEID-AMC (ammonium acetate salt)
Ac-VEID-AMC (ammonium acetate salt)

Item number: Cay14989-1

Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis. It has also been reported to be cleaved by related proteases, including caspase-8. Caspase activity can be quantified by fluorescent detection of free AMC (also known as...
Keywords: Caspase-6 Substrate (Fluorogenic), N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-Methylcoumarin,...
Application: Fluorogenic caspase-6 substrate
MW: 673.7 D
From 94.00€ *
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Calcein AM
Calcein AM

Item number: Cay14948-1

Calcein AM is a cell-permeable dye that, upon entering live cells, is cleaved by intracellular esterases, leaving membrane-impermeant calcein (Cay-16221), a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively. It can be used as an indicator of cell viability, cell-cell...
Keywords: Calcein Acetoxymethyl ester, NSC 689290,...
Application: Cell-permeable dye, cell viability assays
CAS 148504-34-1
MW: 994.9 D
From 98.00€ *
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