PluriSln 1

PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs). PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing progenitor and differentiated cells. Because PluriSln 1 can selectively eliminate undifferentiated hPSCs, it was developed as a strategy to prevent tumorigenic risk from residual undifferentiated cells used during stem cell therapy. In immunocompromised mice, PluriSln 1 has been shown to effectively prevent teratoma formation from undifferentiated hPSCs.Formal Name: 2-phenylhydrazide-4-pyridinecarboxylic acid. CAS Number: 91396-88-2. Synonyms: N'-phenyl-hydrazine-Isonicotinic acid, NSC 14613. Molecular Formula: C12H11N3O. Formula Weight: 213.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 235, 271 nm. SMILES: O=C(NNC1=CC=CC=C1)C2=CC=NC=C2. InChi Code: InChI=1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16). InChi Key: HUDWXDLBWRHCKO-UHFFFAOYSA-N.