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Platelet Derived Growth Factor-D, His tag, human recombinant (rHuPDGFD-His)
Product information "Platelet Derived Growth Factor-D, His tag, human recombinant (rHuPDGFD-His)"
Human recombinant PDGFD produced in E.coli is a single polypeptide chain containing 146 amino acids (250-370) and having a molecular mass of 16.6 kDa. PDGFD is fused to a 25 amino acid His-tag at N-terminus. Platelet-derived growth factor D (PDGFD) belongs to the platelet-derived growth factor family. PDGFD gene product only forms homodimers and, thus, does not dimerize with the other 3 family members. PDGFD has an imperative role in wound healing. PDGFD induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. PDGFD initiates events which lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. The 4 members of the PDGF family are mitogenic factors for cells of mesenchymal origin and are distinguished by a core motif of eight cysteines, 7 of which are found in this factor. PDGFD differs from alpha and beta members of this family by having an odd N-terminal domain, the CUB domain.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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