10 products were found matching "P4258-11.10"!

Platelet Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and connective tissue. PDGF, which is composed of a dimer of two chains termed the A chain and B chain, can be present as AA or BB homodimers or as an AB heterodimer. Source: Recombinant...

Recombinant Mouse PDGF-BB is a homodimeric, non-glycosylated, polypeptide chain containing 109 amino acids and having a molecular mass of 25kD. PDGF is a mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells...

Human PDGF-AA homodimer is produced by genetically engineered yeast, and purified by ionic exchange chromatography and reverse-phase HPLC. This polypeptide is composed of two identical polypeptide chains attached by disulfide bonds. Biological Activity: Human PDGF-AA homodimer is fully active as measured by the...

This recombinant human PDGF-BB expressed in yeast is composed of two identical polypeptide chains attached by disulfide bonds. The polypeptide chains have been partially cleaved between Arg-32 and Thr-33 (see US Patent #s 6083910 and 5895755). This cleavage is visible upon reduction of the polypeptide with a...

Platelet-derived growth factor receptor (PDGFR) is a transmembrane glycoprotein of 170-185kD which undergoes homo- or heterodimerization into complexes of a and b subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB or -AB) that binds. The phosphorylation of tyrosine residues in the...

The proteins of the platelet derived growth factor (PDGF) family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor a (PDGFRa) and PDGF receptor B (PDGFRb). PDGFra and...

PDGFRa, also known as platelet derived growth factor receptor alpha, is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This protein can bind to both A and B subunits of PDGF. It is particularly important for kidney development since mice heterozygous for the...

Human PDGFRb GenBank Accession No. NM_002609), cytoplasmic domain with N-terminal GST tag, expressed in a Baculovirus infected Sf9 cell expression system. Specific Activity: 3 units/ug (1 unit is defined as transfer of 1 pmol phosphate to the substrate peptide KKKSKDESVDYVPMLDMKG per minute at 30°C). Applications:...

Source:, Sf9, Biological Activity: The material is able to bind the ligand (PDGF) as demonstrated by immobilizing the PDGF receptor extracellular domain and establishing competition of binding with radioiodinated PDGF. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute to with sterile...

Applications: , Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 20ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and...