34 products were found matching "P4072-05P"!

Human PDE5A (GenBank Accession No. NM_001083), full length with N-terminal GST tag, expressed in a Baculovirus infected Sf9 cell expression system. Specific Activity: ~3000 pmol/min/ug , Activity: Quantified by 5'-nucleotidase cleaving the 5'GMP product and releasing the phosphate group which was detected by...

The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G protein coupled receptors (GPCRs) for hormones, cytokines, and...

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle...

Human PDE6D was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase, PDE6. Catalytically active PDE6 is a heterodimer (ab) that is regulated by two inhibitory gamma subunits. As PDE6D does not modify the catalytic properties of PDEab, its function is still unresolved. Recombinant human...

Spleen exonuclease (Phosphodiesterase II) hydrolyzes 3'-phosphomononucleotides from oligonucleotides containing a 5'-hydroxyl terminus. The enzyme's specificity for the 5'-phosphate end of a polynucleotide chain after conversion to 5'-OH by use of E. coli alkaline phosphatase makes spleen exonuclease very important...

Mouse PDE2A (GenBank Accession No. NM_002599), full length with N-terminal GST tag, expressed in a Baculovirus infected Sf9 cell expression system. Specific Activity: 2080pmol/min/ug, Assay Conditions: 10mM Tris-HCl, pH 7.4, 10mM MgCl2, 1mM MnCl2, 200uM cGMP, 2.5kU 5'nucleotidase, 37°C, 20 min. Applications:...

Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-PDE11) based on their kinetic properties and inhibition to various pharmacological agents. The members of the PDE3 families are known...

Human PDE4A1A (GenBank Accession No. U97584), full length protein with N-terminal GST tag (MW = 100kD), expressed in a Baculovirus infected Sf9 cell expression system. Specific Activity: Lot Specific. Sample Lot Value: 4,176 pmol/min/ug. Unit Definition: One unit is defined as the amount of enzyme that will...

Human PDE4B1 (GenBank Accession No. NM_001037341), full length with N-terminal GST tag (MW: 109kD), expressed in a Baculovirus infected Sf9 cell expression system. Specific Activity: Lot-specific. Sample Lot Value: 8532 pmol/min/ug. Unit Definition: 1 unit is defined as the amount of enzyme that will convert 1...

Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5, 1, 2). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in...

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. Four genes (PDE4A, B, C...

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced...