20 products were found matching "P4070-58"!

Phenytoin is an anticonvulsant drug which can be useful in the treatment of epilepsy. Phenytoin blocks voltage-sensitive sodium channels in neurons. This action leads to a delay in neuronal electrical recovery. Phenytoin's inhibitory effect is dependent on the voltage and frequency of neural cell firing by...

Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium.[2][3][4][5][6] The structure of phorbol was determined in...

Widely used PKC activator, less potent than PMA, but also less hydrophobic, making it easier to wash out of cells in tissue culture. This was the ligand used, in radioactive form, in the discovery of the phorbol ester receptor. Solubility: Soluble in DMSO or ethanol. Storage and Stability: May be stored at RT for...

Negative control for studies with Phorbol 12,13-Didecanoate. Solubility: Soluble in DMSO or ethanol. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Selective antibiotic for the Sh ble gene, This unique antibiotic shows high toxicity in mammalian cells, plants, yeasts and bacteria. Ocin acts by binding to DNA and cleaving it causing cell death. Ocin is a copper-chelated glycopeptide antibiotic isolated from culture broth of a Streptomyces verticullus mutant and...

PHLPPL (PH domain leucine-rich repeat-containing protein phosphatase-like) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPPL has been demonstrated to trigger apoptosis and...

PHLPP1 is the protein phosphatase responsible for dephosphorylation of the Akt (Ser473) site. Akt (Ser473) is the TORC2 (mTOR) phosphorylation activation site. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1,000 , Optimal...

PHLPP1 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Applications: Suitable...

PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of...

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53...

PHLPP2, a protein phosphatase and negative regulator, which mediates the inactivation of Akt and protein kinase C (PKC) activity, through the direct dephosphorylation of key regulatory sites: AKT1 (Ser473), PRKCA (Ser657) and PRKCB isoform beta-II (Ser660). PHLPP2, and its alternative isoform PHLPP1, have been...

The amyloid beta-peptide (Ab) of 39-43aa (Ab40, Ab42, Ab43) is constitutively produced in brain upon proteolysis of the b-amyloid precursor protein (APP). In the young and healthy humans, Ab is rapidly catabolized before it can be deposited in the brain. However, upon aging or the onset of familial Alzheimer's...