9 products were found matching "Cay16135"!

Phentolamine is a reversible antagonist of alpha-adrenergic receptors, non-specifically binding all alpha1- and alpha2-adrenoceptors with nanomolar affinities. Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.Formal Name:...

UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...

Cefoperazone is a cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram-negative bacteria, including beta-lactamase strains (3-4 µg/ml inhibits 90% of S. aureus growth). It has been studied in the treatment of upper and lower respiratory tract infections, urinary tract infections,...

Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal beta-glucosidase (Ki = 0.016-0.025 µM, IC50 = 0.06 µM). By interacting with the catalytic pocket of beta-glucosidase it acts as a chemical chaperone that increases the amount of beta-glucosidase by stabilizing and/or promoting the folding of the...

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of...

Rifaximin is an antibiotic derived from rifamycin SV (Cay-21441) that inhibits the growth of a variety of Gram-positive and Gram-negative bacteria in vitro, including Staphylococcus, Streptococcus, Enterococcus, H. influenzae, and N. gonorrhoeae (MIC50s = =0.015, 50 = ~20 µM) that reduces colonic damage, rectal...

Prostaglandin F2alpha (PGF2alpha) 1,9-lactone is a lipid-soluble internal ester of PGF2alpha. It is resistant to hydrolysis by human plasma esterases even after incubation for 20 hours under physiological conditions. PGF2alpha 1,9-lactone exhibits little antifertility and vasoactivity compared to PGF2alpha.Formal...

trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.). It has antioxidant and antiradical properties and has shown neuroprotective effects (EC50s = 0.9-3.7 µM) in several in vitro models of neuronal death.Formal Name:...

Sotalol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs, IC50s = 8.9 and 5.2 µM for beta1- and beta2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in...