The peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors within the nuclear receptor superfamily which play important roles in adipogenesis, glucose homeostasis and inflammation. Three different isotypes can be distinguished: alpha, beta and gamma. PPAR-g is mainly expressed...

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins...