Paliperidone

Paliperidone
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15556-25 25 mg -

6 - 10 business days*

98.00€
Cay15556-50 50 mg -

6 - 10 business days*

185.00€
Cay15556-100 100 mg -

6 - 10 business days*

310.00€
Cay15556-500 500 mg -

6 - 10 business days*

1,151.00€
 
Paliperidone is an atypical antipsychotic. It is an inverse agonist of dopamine D2 and D3... more
Product information "Paliperidone"
Paliperidone is an atypical antipsychotic. It is an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively), as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively). Paliperidone also binds to alpha1- and alpha2-adrenergic receptors, histamine H1 receptors, and the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively). It improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia when administered at a dose of 0.05 mg/kg per day. Paliperidone is also an active metabolite of the atypical antipsychotic risperidone (Cay-13629). Formulations containing paliperidone have been used in the treatment of schizophrenia and schizoaffective disorder.Formal Name: 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. CAS Number: 144598-75-4. Synonyms: 9-hydroxy Risperidone, RO76477. Molecular Formula: C23H27FN4O3. Formula Weight: 426.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. lambdamax: 237, 279 nm. SMILES: OC1C(N2CCC1)=NC(C)=C(CCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)C2=O. InChi Code: InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3. InChi Key: PMXMIIMHBWHSKN-UHFFFAOYSA-N.
Keywords: 9-hydroxy Risperidone, RO76477, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Supplier: Cayman Chemical
Supplier-Nr: 15556

Properties

Application: Dopamine D2/3-receptor / 5-HT2A-receptor antagonist
MW: 426.5 D
Formula: C23H27FN4O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 144598-75-4| Matching products
KEGG ID : K04145 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301
P Phrases: P264, P270, P301+310, P321, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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