PX 12

PX 12
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14192-1 1 mg -

6 - 10 business days*

43.00€
Cay14192-5 5 mg -

6 - 10 business days*

94.00€
Cay14192-10 10 mg -

6 - 10 business days*

146.00€
 
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to... more
Product information "PX 12"
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA. Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1alpha protein levels (IC50 = 7.2 µM), as well as expression of VEGF (IC50 = 10.4 µM) and iNOS (IC50 = 18.1 µM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 µM) and HT-29 cells (IC50 = 2.9 µM) as well as reduced microvessel density in MCF-7 tumor xenografts. PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 µM) and Trx-1-increased expression and translation of CYP1B1.Formal Name: 2-[(1-methylpropyl)dithio]-1H-imidazole. CAS Number: 141400-58-0. Molecular Formula: C7H12N2S2. Formula Weight: 188.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 14 mg/ml, Ethanol: 20 mg/ml. lambdamax: 235 nm. SMILES: CC(CC)SSC1=NC=CN1. InChi Code: InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9). InChi Key: BPBPYQWMFCTCNG-UHFFFAOYSA-N.
Keywords: 2-[(1-methylpropyl)dithio]-1H-imidazole
Supplier: Cayman Chemical
Supplier-Nr: 14192

Properties

Application: Trx1 inhibitor
MW: 188.3 D
Formula: C7H12N2S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 141400-58-0| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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PX-12 PX-12
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