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PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to... more
Product information "PX 12"
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA. Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1alpha protein levels (IC50 = 7.2 µM), as well as expression of VEGF (IC50 = 10.4 µM) and iNOS (IC50 = 18.1 µM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 µM) and HT-29 cells (IC50 = 2.9 µM) as well as reduced microvessel density in MCF-7 tumor xenografts. PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 µM) and Trx-1-increased expression and translation of CYP1B1.Formal Name: 2-[(1-methylpropyl)dithio]-1H-imidazole. CAS Number: 141400-58-0. Molecular Formula: C7H12N2S2. Formula Weight: 188.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 14 mg/ml, Ethanol: 20 mg/ml. lambdamax: 235 nm. SMILES: CC(CC)SSC1=NC=CN1. InChi Code: InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9). InChi Key: BPBPYQWMFCTCNG-UHFFFAOYSA-N.
Keywords: | 2-[(1-methylpropyl)dithio]-1H-imidazole |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14192 |
Properties
Application: | Trx1 inhibitor |
MW: | 188.3 D |
Formula: | C7H12N2S2 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 141400-58-0| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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