8 products were found matching "Cay10009746-100"!

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AM630
AM630

Item number: Cay10006974-100

AM630 binds selectively to cannabinoid 2 (CB2) over CB1 receptors with Ki values of 31.2 and 5,152 nM, respectively. AM630 acts as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. It decreases proliferation and...
Keywords: 6-Iodopravodoline, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone
Application: CB2 receptor antagonist
CAS 164178-33-0
MW: 504.4 D
From 77.00€ *
Review
PTEN (human recombinant)
PTEN (human recombinant)

Item number: Cay10009746-50

Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as AKT and phosphatidylinositol 3,4,5-trisphosphate (PIP3). PTEN interacts with many other proteins to regulate cell division and migration,...
Keywords: PTEN, MMAC1, Phosphatase and tensin homolog, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1,...
Application: Enzyme activity
MW: 50,8 kD
611.00€ *
Review
CAY10602
CAY10602

Item number: Cay10009796-100

CAY10602 is an activator of sirtuin 1 (SIRT1). It inhibits LPS-induced TNF-alpha release in THP-1 cells when used at concentrations of 20 and 60 µM. CAY10602 (5 µM) decreases the expression of GPX4, SLC7A11, and SLC3A2, as well as increases the levels of iron and malondialdehyde (MDA), in A549 lung and MDA-MB-231...
Keywords: 1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
Application: SIRT1 activator
CAS 374922-43-7
MW: 418.4 D
From 40.00€ *
Review
Lipid-based Drug Delivery Tools
C16 Sphingomyelin (d18:1/16:0)
C16 Sphingomyelin (d18:1/16:0)

Item number: Cay10007946-10

C16 Sphingomyelin is a naturally occurring sphingolipid. Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease. Plasma levels of C16 sphingomyelin...
Keywords: N-Palmitoyl-D-erythro-Sphingosylphosphorylcholine, Palmitoyl Sphingomyelin, SM(d18:1/16:0), Sphingomyelin (d18:1/16:0),...
Application: Bioactive Lipid Assays
CAS 6254-89-3
MW: 703 D
From 94.00€ *
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Acid Phosphatase Assay Buffer (10X)
Acid Phosphatase Assay Buffer (10X)

Item number: Cay10009146-1

Formulation: 1 M HEPES, pH 5.0.
Application: Acid Phosphatase assay
24.00€ *
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6(S)-Lipoxin A4
6(S)-Lipoxin A4

Item number: Cay10049-100

6(S)-Lipoxin A4 (6(S)-LXA4) is an isomer of the trihydroxy fatty acid LXA4 (Cay-90410). It is formed from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) through double lipoxygenase-catalyzed reactions initiated by either 5-lipoxygenase (5-LO) followed by 12- or 15-LO, with a leukotriene A4 (LTA4)...
Keywords: 5(S),6(S),15(S)-TriHETE, 5(S),6(S)-Lipoxin A4, 6(S)-LXA4, 6-epi-Lipoxin A4,...
Application: Bioactive lipid studies
CAS 94292-80-5
MW: 352.5 D
From 368.00€ *
Review
Laurdan
Laurdan

Item number: Cay19706-100

Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of laurdan can be used to identify phospholipid phase. When excited at 340 nm, GP values are 0.6 and -0.2 for gel...
Keywords: 1-[6-(dimethylamino)-2-naphthalenyl]-1-dodecanone
Application: Membrane permeable fluorescent probe, GP quantitation
CAS 74515-25-6
MW: 353.5 D
From 64.00€ *
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URB597
URB597

Item number: Cay10046-100

URB597 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme that hydrolyzes anandamide (AEA, Cay-90050) and other simple esters and amides with long unsaturated acyl chains (IC50 = 4.6 nM and 0.5 nM in brain membranes and intact neurons, respectively). URB597 exhibits both...
Keywords: (3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl)-cyclohexylcarbamate
Application: FAAH inhibitor
CAS 546141-08-6
MW: 338.4 D
From 54.00€ *
Review