PRMT6 (human recombinant, baculovirus expressed)

PRMT6 (human recombinant, baculovirus expressed)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13866-50 50 µg - -

6 - 10 business days*

646.00€
 
Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved... more
Product information "PRMT6 (human recombinant, baculovirus expressed)"
Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of omega-NG-monomethylarginine and asymmetric omega-NG,NG-dimethylarginine on both histone and non-histone targets. Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6. H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed Lineage Leukemia complex methyltransferase. Non-histone targets of PRMT6 include the nuclear high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity.Synonyms: Histone Arginine N-methyltransferase PRMT6, HRMT1L6, Protein Arginine Methyltransferase 6. Purity: >60%. Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells. Amino Acids: 2-375 (full length). MW: 43.7 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol. UniProt Accession #: Q96LA8.
Keywords: PRMT6, HRMT1L6, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 6, Histone-arginine N-methyltransferase PRMT6, Histone-arginine N-methyltransferase PRMT6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein
Supplier: Cayman Chemical
Supplier-Nr: 13866

Properties

Application: Enzyme activity
Conjugate: No
Host: Insect cells
Species reactivity: human
MW: 43,7 kD
Purity: >60%

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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