- Search results for Cay10750-25
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10 products were found matching "Cay10750-25"!
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Item number: Cay17502-5
Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or...
Keywords: | rel-2R,6S-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide |
Application: | ATM kinase inhibitor |
CAS | 925701-46-8 |
MW: | 547.7 D |
From 39.00€
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Item number: Cay10702-5
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD...
Keywords: | 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
Application: | JAK2 inhibitor |
CAS | 935666-88-9 |
MW: | 348.8 D |
From 50.00€
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Item number: Cay10720-500
JWH 073 7-hydroxyindole metabolite-d7 contains seven deuterium atoms at the 2, 2', 3, 3', 4, 4, and 4 positions. It is intended for use as an internal standard for the quantification of JWH 073 7-hydroxyindole metabolite by GC- or LC-mass spectrometry (MS). JWH 073 is a mildly selective agonist of the central...
Keywords: | (1-butyl-2,2,3,3,4,4,4-d7-7-hydroxy-1H-indol-3-yl)-1-naphthalenyl-methanone |
Application: | Analytical reference standard, GC-MS, LC-MS internal standard, Quantification |
CAS | 2749316-88-7 |
MW: | 350.5 D |
From 339.00€
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Item number: Cay10755-50
Post-translational modification of histones by methylation of lysine residues can promote transcriptional activation or repression. G9a-like protein (GLP) and G9a are SET domain-containing methyltransferases that specifically mono- and di-methylate histone H3 at lysine 9 (H3K9). Methylation of H3K9 by a GLP/G9a...
Keywords: | GLP, GLP, GLP1, GLP1, EHMT1, EUHMTASE1, Eu-HMTase1, Eu-HMTase1, H3-K9-HMTase 5, H3-K9-HMTase 5, G9a-like protein 1,... |
Application: | Enzyme activity |
Expressed in: | E.coli |
MW: | 60,3 kD |
530.00€
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Item number: Cay28464-1
CAY10755 is a fungal metabolite that has been found in P. macrospinosa and has anticancer activity. It is cytotoxic to A549, H116, PSN-1, and T98G cancer cells (IC50s = 4.6, 4, 2.2, and 7.7 µM, respectively).Formal Name:...
Keywords: | 3a,4,5,6,6a,9,9a,9b-octahydro-3a-hydroxy-2-(hydroxymethyl)-5,8,9a-trimethyl-9-(1-methyl-1-propen-1-yl)-1H -phenalen-1-one |
Application: | Fungal metabolite, Antineoplastic |
CAS | 1262489-36-0 |
MW: | 330.5 D |
261.00€
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Item number: Cay15725-25
Bufalin is a cardiotonic steroid first isolated from toad venom and used in traditional Asian medicine. It inhibits the Na+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the alpha1, alpha2, and alpha3 subunits, respectively). Intravenously administered bufalin is cleared rapidly, with a plasma half-life of 25...
Keywords: | NSC 89595, (3beta,5beta)-3,14-dihydroxy-bufa-20,22-dienolide |
Application: | Na+/K+-ATPase transporter inhibitor, SRC-1/3 inhibitor |
CAS | 465-21-4 |
MW: | 386.5 D |
From 77.00€
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Item number: Cay15007-25
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...
Keywords: | DOX,... |
Application: | DNA topoisomerase II inhibitor, Antitumor agent |
CAS | 25316-40-9 |
MW: | 580 D |
From 43.00€
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Item number: Cay15025-5
Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Cay-70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond. This bond is rapidly cleaved by bacteria in the terminal ileum and colon, releasing the active anti-inflammatory component. Sulfasalazine (0.1-5...
Keywords: | Azopyrin, NSC 203730, NSC 667219, 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-benzoic acid |
Application: | Apoptosis inducer |
CAS | 599-79-1 |
MW: | 398.4 D |
From 60.00€
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Item number: Cay10075-25
Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2. However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example. CAY10452 is a celecoxib analog that retains potent, selective COX-2...
Keywords: | PTPBS, 4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide |
Application: | COX-2 inhibitor |
CAS | 170569-87-6 |
MW: | 367.3 D |
From 43.00€
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Item number: Cay20750-5
11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the omega-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid (Cay-90330), a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5'-monophosphate dehydrogenase (Ki = 3.1 µM) and inhibits the binding of LTB4...
Keywords: | 11Z,14Z-eicosadienoic acid, methyl ester |
CAS | 61012-46-2 |
MW: | 322.5 D |
From 34.00€
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