- Search results for Cay15759
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26 products were found matching "Cay15759"!
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Item number: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
Keywords: | gamma-Secretase Inhibitor XXI,... |
Application: | gamma-Secretase inhibitor |
CAS | 209986-17-4 |
MW: | 490.5 D |
From 254.00€
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Item number: Cay15779-5
Oseltamivir (GS-4104) is an antiviral prodrug targeted against the influenza viruses. Oseltamivir acid is the active metabolite of oseltamivir. It acts as an inhibitor of influenza neuraminidases A and B (IC50 = 0.1 to 4.9 nM for both enzymes), in this way preventing virus budding and release.Formal Name:...
Keywords: | GS-4071, Ro 64-0802, 4R-(acetylamino)-5S-amino-3R-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid |
Application: | Influenza neuraminidase A & B inhibitor |
CAS | 187227-45-8 |
MW: | 284.4 D |
From 66.00€
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Item number: Cay17559-5
Galantamine is an alkaloid that has been found in Galanthus and has acetylcholinesterase (AChE) inhibitory and nicotinic acetylcholine receptor (nAChR) potentiating activities. It selectively inhibits AChE over butyrylcholinesterase (BChE, IC50s = 636 and 8,404 nM, respectively). Galantamine (0.5 µM) potentiates...
Keywords: | Galanthamine, NSC 100058,... |
Application: | AChE inhibitor, nAChR allosteric site agonist |
CAS | 357-70-0 |
MW: | 287.4 D |
From 65.00€
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Item number: Cay15379-5
Complex I, also known as NADH:ubiquinone oxidoreductase or NADH dehydrogenase (ubiquinone), catalyzes the transfer of electrons from NADH to ubiquinone (also known as coenzyme Q10) as part of the respiratory chain leading to ATP generation. Piericidin A is an irreversible inhibitor of mitochondrial complex I that...
Keywords: | AR 054, Shaoguanmycin B, SN 198E,... |
Application: | Mitochondrial Complex I inhibitor |
CAS | 2738-64-9 |
MW: | 415.6 D |
From 171.00€
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Item number: Cay15279-5
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. CAL-101 is a cell permeable inhibitor of the PI3K catalytic subunit p110delta (IC50 = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC50s = 820, 565, and...
Keywords: | Idelalisib, GS-1101, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone |
Application: | Cell permeable PIK3CD inhibitor |
CAS | 870281-82-6 |
MW: | 415.4 D |
From 44.00€
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Item number: Cay13579-5
Cancer stems cells (CSCs) are a subpopulation of cells within tumors that drive tumor growth and recurrence. They are resistant to many current cancer treatments. Salinomycin (sodium salt) is an antibacterial and coccidiostat compound that shows selective toxicity for the CSCs that exist as a subpopulation within...
Keywords: | alpha-ethyl-6-[5-[2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[... |
Application: | Tumor growth inhibitor, Antiprotozoal, Coccidiostat |
CAS | 53003-10-4 |
MW: | 751 D |
From 34.00€
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Item number: Cay19579-5
Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane. It associates with growth factor receptors, including TrkA,...
Keywords: | GM1 Mixture, Monosialoganglioside GM1 Mixture |
Application: | Cholera toxin binding site |
MW: | 1546.8 D |
From 84.00€
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Item number: Cay14579-5
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of...
Keywords: | NG 60, (2R)-2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
Application: | CDK inhibitor |
CAS | 212844-53-6 |
MW: | 388.9 D |
From 43.00€
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Item number: Cay15479-5
(+)-JQ1 (Cay-11187) binds to the acetyl-lysine recognition pocket of bromodomains 1 and 2 on BRD4 with Kd values of ~50 and 90 nM, respectively. This displaces BRD4 from nuclear chromatin in cells, inducing differentiation and growth arrest in midline carcinoma cells. CPI-203 is a primary amide analog of (+)-JQ1...
Keywords: | (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
Application: | BRD4 binding inhibitor |
CAS | 1446144-04-2 |
MW: | 399.9 D |
From 77.00€
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Item number: Cay11579-5
Glipizide is a hypoglycemic agent. It inhibits ATP-sensitive potassium (KATP) channels in primary mouse pancreatic beta cells (IC50 = 6.4 nM). Glipizide induces insulin release from isolated rat pancreatic tissue with an EC50 value of 40 nM. Dietary administration of glipizide (5 mg/kg per day for 10 days) increases...
Keywords: | CP 28720, K 4024, TK 1320, N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-2-pyrazinecarboxamide |
Application: | Sulfonylurea receptor agonist, Hypoglycemic agent |
CAS | 29094-61-9 |
MW: | 445.5 D |
From 40.00€
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Item number: Cay15179-5
ML-161 is an allosteric, reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM. It blocks platelet activation induced by thrombin as well as by SFLLRN but not by PMA (Cay-10008014), U-46619...
Keywords: | AG-670, CID-1048267, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide |
Application: | PAR1 inhibitor |
CAS | 423735-93-7 |
MW: | 361.2 D |
From 43.00€
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Item number: Cay17579-5
L-alpha-Aminoadipic acid is a gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase with a Ki value of 209 µM. It actively accumulates in glial cells and inhibits the glutamate transporter with a Ki value of 192 µM.Formal Name: 2S-amino-hexanedioic acid. CAS...
Keywords: | (S)-2-Aminohexanedioic Acid, 2S-amino-hexanedioic acid |
Application: | Glutamine synthetase inhibitor, Glutamate transporter inhibitor |
CAS | 1118-90-7 |
MW: | 161.2 D |
From 43.00€
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