- Search results for Cay16275
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10 products were found matching "Cay16275"!
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Item number: Cay16275-50
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). PPQ-102 is a cell-permeable pyrimido-pyrrolo-quinoxalinedione that reversibly inhibits CFTR chloride channels with an IC50 value of 90 nM. At 0.5-5 µM, PPQ-102 has been used to reduce the size...
Keywords: | CFTR Inhibitor IV, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV,... |
Application: | CFTR inhibitor |
CAS | 931706-15-9 |
MW: | 438.5 D |
From 121.00€
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Item number: Cay16227-5
Nourseothricin is a broad-spectrum antibiotic produced by Streptomyces variants that inhibits protein synthesis by inducing miscoding. It is commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells. Selection of recombinant strains is...
Keywords: | clonNAT, Streptothricin, nourseothricin, monosulfate |
Application: | Broad-spectrum antibiotic |
CAS | 96736-11-7 |
MW: | 1359.5 D |
From 43.00€
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Item number: Cay16277-5
Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 µM) that...
Keywords: | N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine |
Application: | BMI-1 inhibitor |
CAS | 315704-66-6 |
MW: | 495.2 D |
From 39.00€
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Item number: Cay16274-5
Bruton's tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation,...
Keywords: | Imbruvica, PCI 32765, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
Application: | BTK inhibitor |
CAS | 936563-96-1 |
MW: | 440.5 D |
From 50.00€
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Item number: Cay16276-5
PR-619 is a general inhibitor of deubiquitylating enzymes (DUBs), significantly reducing the activity of a panel of DUBs with EC50 values ranging from 5-20 µM. It is cell-permeable and reversible in its action. It is selective for DUBs over other proteases. PR-619 induces the accumulation of polyubiquitinated...
Keywords: | 2,6-Diamino-3,5-dithiocyanopyridine, DUB Inhibitor V, thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester |
Application: | DUB inhibitor |
CAS | 2645-32-1 |
MW: | 223.3 D |
From 80.00€
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Item number: Cay16271-5
The immunoproteasome is a specialized, inducible proteasome that generates peptides presented on major histocompatibility complex (MHC) class I molecules to cytotoxic T cells. Stimulation of cells with inflammatory cytokines such as IFN-gamma leads to the replacement of constitutive catalytic proteasome beta...
Keywords: | PR-957,... |
Application: | Immunoproteasome inhibitor |
CAS | 960374-59-8 |
MW: | 580.7 D |
From 84.00€
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Item number: Cay16272-5
Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). It...
Keywords: | 2-p-tolyl-1,2-Benzisothiazolin-3-one, 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one |
Application: | JARID1B inhibitor |
CAS | 2514-30-9 |
MW: | 241.3 D |
From 50.00€
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Item number: Cay16278-5
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2...
Keywords: | N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-urea |
Application: | ROCK inhibitor |
CAS | 1342278-01-6 |
MW: | 326.4 D |
From 82.00€
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Item number: Cay16273-5
PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma...
Keywords: | Palbociclib, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one,... |
Application: | Cyclin-dependent kinase 4/6 (CDK4/6) inhibitor |
CAS | 827022-32-2 |
MW: | 484 D |
From 50.00€
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Item number: Cay16279-5
S1RA is a sigma-1 (sigma1) receptor antagonist (Ki = 17 nM). It is selective for sigma1 receptors over sigma2 receptors (Ki = 9,300 nM), as well as a panel of 170 additional receptors at 1 µM. S1RA reduces capsaicin-induced mechanical allodynia, formalin-induced licking and biting behavior, and partial sciatic nerve...
Keywords: | E-52862, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholine |
Application: | SIGMAR1 antagonist |
CAS | 878141-96-9 |
MW: | 337.4 D |
From 109.00€
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