- Search results for Cay15729
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18 products were found matching "Cay15729"!
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Item number: Cay14759-25
IPA-3 is an allosteric inhibitor of p21-activated kinase 1 (PAK1) activation (IC50 = 2.5 µM) that does not inhibit pre-activated PAK1. It selectively inhibits activation of the group I PAKs, PAK1, PAK2, and PAK3 over the group II PAKs, PAK4, PAK5, and PAK6 at 10 µM. IPA-3 inhibits the severe acute respiratory...
Keywords: | 1,1'-dithiobis-2-naphthalenol |
Application: | PAK1 inhibitor |
CAS | 42521-82-4 |
MW: | 350.5 D |
From 77.00€
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Item number: Cay10005729-1
To be used in conjunction with Cayman's 11beta-HSD1 Polyclonal Antibody (Cay-10004303) to block protein-antibody complex formation during immunochemical analysis of 11beta-HSD1.Synonyms: 11beta-HSD1, Corticosteroid 11beta-Dehydrogenase Isozyme 1. Amino Acids: Human 11beta-HSD1 amino acids 78-92 (CLELGAASAHYLAGT)....
Keywords: | 11beta-HSD1, Corticosteroid 11beta-Dehydrogenase Isozyme 1 |
Application: | IHC, WB |
177.00€
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Item number: Cay15279-5
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. CAL-101 is a cell permeable inhibitor of the PI3K catalytic subunit p110delta (IC50 = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC50s = 820, 565, and...
Keywords: | Idelalisib, GS-1101, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone |
Application: | Cell permeable PIK3CD inhibitor |
CAS | 870281-82-6 |
MW: | 415.4 D |
From 44.00€
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Item number: Cay17529-5
The lysophosphatidic acid (LPA) receptor LPA2 is a G protein-coupled receptor that has roles in protecting against radiation-induced cell death. DBIBB is a non-lipid agonist of LPA2 (EC50 = 0.10 µM) that is without effect at other LPA receptor subtypes. It protects rat intestinal crypt epithelium-like IEC-6 cells...
Keywords: | 2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid |
Application: | LPA2 agonist |
CAS | 1569309-92-7 |
MW: | 452.5 D |
From 77.00€
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Item number: Cay15297-10
BAY 85-3934 is a pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PH, IC50s = 0.48, 0.28, and 0.45 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It stabilizes HIF-1alpha and HIF-2alpha levels in HeLa cells in a concentration- and time-dependent manner. BAY 85-3934 (50 µM) induces cell-cycle...
Keywords: | Molidustat, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one |
Application: | HIF-1alpha prolyl hydroxylase inhibitor |
CAS | 1154028-82-6 |
MW: | 314.3 D |
From 44.00€
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Item number: Cay15790-25
17,20-dimethyl Prostaglandin F1alpha (17,20-dimethyl PGF1alpha) is an analog of the limaprost family with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an analog of PGE1 which is orally active in both rats and guinea pigs. The additional methyl groups in the...
Keywords: | 17,20-dimethyl PGF1alpha, 9alpha,11alpha,15S-trihydroxy-17S,20-dimethyl-prost-13E-en-1-oic acid |
Application: | Bioactive lipid assays |
MW: | 384.6 D |
From 86.00€
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Item number: Cay10009557-25
The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent...
Keywords: | Pluripotin,... |
Application: | RasGAP/ERK1 inhibitor |
CAS | 839707-37-8 |
MW: | 550.5 D |
From 77.00€
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Item number: Cay19572-1
Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6). It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1, IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.Formal...
Keywords: | Hyp-DCHA, Hyperforin-DCHA,... |
Application: | Phytochemical |
CAS | 238074-03-8 |
MW: | 718.1 D |
From 180.00€
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Item number: Cay17729-5
Ferrostatin-1 is a ferroptosis inhibitor. It inhibits cell death induced by the ferroptosis inducers erastin (Cay-17754, EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 µM. Ferrostatin-1 (0.5 µM) inhibits erastin-induced...
Keywords: | Fer-1, 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester |
Application: | Ferroptosis inhibitor |
CAS | 347174-05-4 |
MW: | 262.4 D |
From 68.00€
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Item number: Cay19057-25
Sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis. Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various...
Keywords: | Oxalic Acid monoamide, Oxamic Acid, 2-amino-2-oxo-acetic acid, monosodium salt |
Application: | Glycolysis disruptor, Lactate dehydrogenase inhibitor |
CAS | 565-73-1 |
MW: | 111 D |
From 80.00€
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Item number: Cay14957-25
Adenosine 5'-(gamma-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11). It has been used to identify kinase substrates, has been implemented as a reagent in the synthesis of DNA N-acetylglucosamine analogs,...
Keywords: | ATPgammaS, P'-anhydride with phosphorothioic acid adenosine 5'-(trihydrogen diphosphate), tetralithium salt |
Application: | ATP analog, GPCR P2Y2 / P2Y11 agonist |
CAS | 93839-89-5 |
MW: | 547 D |
From 42.00€
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Item number: Cay19757-25
7-methoxy Apigeninidin is a 3-deoxyanthocyanin fungicide originally isolated from Sorghum and a derivative of apigeninidin (Cay-19756). It is active against the radial growth of G. sorghi and spore germination of P. oryzae (IC50 = 50 ppm for both).Formal Name: 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-1-benzopyrylium,...
Keywords: | 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-1-benzopyrylium, monochloride |
CAS | 161773-51-9 |
MW: | 304.7 D |
From 66.00€
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