PNU 74654

The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. PNU 74654 binds to beta-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU 74654 significantly reduced expression of several Tcf/beta-catenin target genes.Formal Name: 2-phenoxy-benzoic acid, 2-[(5-methyl-2-furanyl)methylene]hydrazide. CAS Number: 113906-27-7. Molecular Formula: C19H16N2O3. Formula Weight: 320.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 318 nm. SMILES: O=C(N/N=C/C1=CC=C(C)O1)C2=CC=CC=C2OC3=CC=CC=C3. InChi Code: InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+. InChi Key: JJEDWBQZCRESJL-DEDYPNTBSA-N.