18 products were found matching "SYN-1069-M100"!

Soluble in DMSO or ethanol. Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR beta, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively. Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ZSTK474 inhibits all four PI3K isoforms in an ATP-competitive manner. IC(50) is approximately 37nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water. PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively. Substrate: Tyrosine

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PIK-75 is a PI3K inhibitor displaying selectivity for the p110alpha isoform (IC(50) of 6nM). PIK-75 blocks the phosphorylation of PKB induced by insulin. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AS-252424 is a potent and selective PI3K inhibitor. It inhibits human recombinant PI3K alpha, beta, gamma and delta with IC(50) values of 30, 940, 20.000, and 20.000nM respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

Soluble in DMSO, Ethanol. Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in...

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PF04217903 is a novel orally bio-available, small molecule tyrosine kinase inhibitor with potential anti-neoplastic activity. It is an extremely selective MET inhibitor, with an IC(50) of 4.8nM. Target: MET , Kinase Group: RTK , Substrate: Tyrosine

PD173955 is an ATP-competitive, dual Src/Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of...

Soluble in DMSO or ethanol. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was...

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PIK-93 selectively inhibits the type III PI 4-kinase beta enzyme (IC(50) of 19nM). It has also been shown to have activity on PI3Kalpha with an IC(50) of 39nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

Slightly soluble (<1mg/ml) in DMSO or ethanol. PIK-90 is a potent PI3K inhibitor with IC(50) values of 11, 18, and 58nM for p110alpha, gamma and delta isoforms respectively. It has an IC(50) of 350nM for the p110beta isoform. It also has low mTOR activity. Target: PI3K , Kinase Group: Lipid Kinase , Substrate:...

Soluble in DMSO or ethanol. SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM). Target: MAPK - p38 , Kinase Group: CMGC , Substrate:...