PF-670462 (hydrochloride)

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1epsilon and CK1delta (IC50 = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related or common kinases. Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals. It also blocks the locomotor response to amphetamines in mice.Formal Name: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine, dihydrochloride. CAS Number: 950912-80-8. Molecular Formula: C19H20FN5 . 2HCl. Formula Weight: 410.3. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 236, 322 nm. SMILES: NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCCC4)=N1.Cl.Cl. InChi Code: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15,,/h6-12,15H,1-5H2,(H2,21,22,24),2*1H. InChi Key: PSNKGVAXBSAHCH-UHFFFAOYSA-N.